Use the "VHD" (Virtual Hard Disk) boot method. You can place a pre-configured Windows 11 64-bit VHD on a USB drive, boot into it, and run Macrium Reflect from there. This provides a true 64-bit portable workspace.
Portable Application Support Explained. Portable application support ships exclusively with Macrium Reflect Technician's Licenses. How To Create Macrium Reflect Bootable Rescue CD/USB Macrium Reflect Portable 64 Bit
Here is everything you need to know.
This environment is 64-bit, runs entirely from memory (RAM), and allows you to restore backups to a new hard drive or scan for viruses on a dormant system. Use the "VHD" (Virtual Hard Disk) boot method
Technician's Portable Application Support | Macrium Software Portable Application Support Explained
For backup and disaster recovery, the Rescue Media is actually superior to a portable application for several reasons:
: Select your USB drive from the list of available devices.