Heavy use of memory patching (like the "No Collision" mode) can lead to game crashes or "soft locks" where progression becomes impossible. Source Integrity:
Leon clutched his handgun. He had nine bullets. He missed the first shot on a Ganado. He panicked. He reached into his attaché case for a herb, but realized he only had a dead fish and a chicken egg. re4 ultimate trainer
Resident Evil 4 (RE4) , particularly the 2005 original and its Ultimate HD Edition Heavy use of memory patching (like the "No