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| Enzyme | IC₅₀ (nM) | |--------|----------| | PI3Kα | | | PI3Kβ | > 10 000 | | PI3Kγ | > 10 000 | | PI3Kδ | > 10 000 |
In recent times, the designation "JUQ-565" has emerged, capturing the attention of various circles. While the specific context or field it relates to might not be widely known, delving into the potential significance and implications of such a designation can offer insights into areas ranging from scientific research to technological advancements. This article aims to inform readers about JUQ-565, exploring its possible meanings, relevance, and the speculation surrounding it.
Recombinant human PI3Kα, β, γ, δ (Carna Biosciences) were incubated with PIP₂ substrate and ATP in the presence of increasing concentrations of JUQ‑565 (0.01 nM – 10 µM). Reaction products were quantified using a luminescent ADP‑Glo assay (Promega). IC₅₀ values were derived by four‑parameter logistic fitting (GraphPad Prism 9).