Open a support case if you have tried all the above and still see the following in the AnyConnect-WebLaunch.log (located in %TEMP%\Cisco ):
If you are trying to connect to your corporate VPN using Cisco AnyConnect Secure Mobility Client version 4.10 and are met with the error message you are not alone. This is a known issue specific to version 4.10, often caused by conflicts with system permissions or browser integrations. failed to launch downloader cisco anyconnect 4.10
If the compliance module version on the local machine is newer than the one configured on the ISE server, AnyConnect may fail as it cannot downgrade the module. Open a support case if you have tried
Temporarily disable firewall or antivirus software (such as NOD32 or McAfee) that might block the vpndownloader.exe Run DART for Deep Analysis: If the issue persists, use the AnyConnect Diagnostics and Reporting Tool (DART) to collect logs for a Cisco TAC case. Cisco Community manually update the compliance module within your ISE environment? AnyConnect - Failed To Launch Downloader - Cisco Community Temporarily disable firewall or antivirus software (such as