Yes, but only at Feature Level 11.1 (not full DirectX 12 Ultimate).
If you see this error on Windows 11:
AMD no longer provides official "new feature" drivers for the FirePro W2100. However, the final compatible driver works well on Windows 11 (64-bit). amd firepro w2100 driver windows 11 link
To revert: bcdedit /set testsigning off
You can download the latest stable driver here:AMD Official Support Page - FirePro W2100 (amd.com) Steps to Install the Driver on Windows 11 Yes, but only at Feature Level 11
But don’t throw away your card yet. In this 2,000+ word guide, we will provide the one safe download link that works, explain the installation process, and offer workarounds for common errors. 000+ word guide