The genius of Sketchy Microbiology lies not in the humor, but in the cognitive psychology underpinning it. The platform utilizes and the Method of Loci (often called the Memory Palace technique).

Before Sketchy, students relied on Clinical Microbiology Made Ridiculously Simple or endless repetition of Lippincott's . Sketchy changed the game for three specific reasons:

The core mechanic of Sketchy Microbiology is its symbol dictionary. To the uninitiated, a Sketchy video looks like a chaotic cartoon. To a medical student, every line, color, and object is a code for a specific medical fact.